Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates (...) and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress. (shrink)

We paraphrase Descartes’ famous dictum in the area of AI ethics where the “I doubt and therefore I am” is suggested as a necessary aspect of morality. Therefore AI, which cannot doubt itself, cannot possess moral agency. Of course, this is not the end of the story. We explore various aspects of the human mind that substantially differ from AI, which includes the sensory grounding of our knowing, the act of understanding, and the significance of being able to doubt ourselves. (...) The foundation of our argument is the discipline of ethics, one of the oldest and largest knowledge projects of human history, yet, we seem only to be beginning to get a grasp of it. After a couple of thousand years of studying the ethics of humans, we (humans) arrived at a point where moral psychology suggests that our moral decisions are intuitive, and all the models from ethics become relevant only when we explain ourselves. This recognition has a major impact on what and how we can do regarding AI ethics. We do not offer a solution, we explore some ideas and leave the problem open, but we hope somewhat better understood than before our study. (shrink)

Purpose. Institutionalism is gaining strength as a dominant point of view on the world. Its philosophical basis is the postulate of the uncertainty of the development, which comes to replace the neoclassical certainty characteristic of industrial society. The postulate of uncertainty is closely connected with the idea of subjectivization and individualization of post-industrial society. All these were very important components of the new paradigm, although they do not exhaust the problem. In the heart of postmodernism is a mass identity as (...) a spiritual substance, while the more recently mass of people to realize themselves as natural and social beings. Person has absolute freedom in the acceptance and rejection of culture and civilization; it is pluralistic in their actions and in their consciousness. It is the subject of history and it should be creative, fluent mastering all the achievements of culture. Methodology. The dialogue system of the Postmodern, which is the basis of human communication with another person, human with society is a model of convergent formation of the world community and world economy. The same model of rationalism and adequate industrial society is a monologue, which is easily builds a bridge to violence, even if it is carried out in the name of the man behind him and the pathos of the exaltation of man as the bearer of unlimited creation possibilities. However, it is very important not just to modify rationalism, and to understand the origins of civilization. Scientific novelty. The postmodern era begins is not easy. Modern defending, using all their reserves: public thirst for justice, the priority of rationality, monologist public agencies and politicians in contrast to the dialogic postmodern imperative modality in the spiritual existence of man instead the freedom. Finally, the world of the story is set a trap – the anthropological paradigm of the globalization ideology formation. In this paradigm, people see materialistic rational measure of space and society building, i.e. the natural and social being, not a spiritual person. All this was evident in the course of transformation in Ukraine. Its main weakness is obvious. This narrows the field of mass participation in the market or by the adopted symbolism, the field of subjectivity. The population is invited to wait and endure, i.e. plays the role of the object of political and economic manipulation. Even more unacceptable monopolization of subjectivity government, for which everything is regarded as a subject of state regulation. Conclusions. For civilization of cardinal feature is the treatment of the person as the subject of history. The need for the development of civilization to increase the degree of subjectivity in an economy where people can express themselves freely and responsibly through a system of private property relations: economic entity is the subject of property. Policy enhancing the role of human rights and the development of the principle of subjectivity means deepening the democratic foundations of the state structure. In the social sphere the subjectivity is expressed in the individualization of the social existence of man and the personification of public relations and it is implemented through the mechanisms of liberal institutions. It seems that the civilizational unity of the economy, democratic state and liberal society has the value of a scientific paradigm. Whatever the great cultural peaks of the postmodern, the main processes of a new society formed at its foot: in the area of formation of public consciousness and public preferences with the mass participation of the individual in the economy, in the field of state-building and the formation of social institutions on the principles of Amateur participation. (shrink)

Purpose. Institutionalism is gaining strength as a dominant point of view on the world. Its philosophical basis is the postulate of the uncertainty of the development, which comes to replace the neoclassical certainty characteristic of industrial society. The postulate of uncertainty is closely connected with the idea of subjectivization and individualization of post-industrial society. All these were very important components of the new paradigm, although they do not exhaust the problem. In the heart of postmodernism is a mass identity as (...) a spiritual substance, while the more recently mass of people to realize themselves as natural and social beings. Person has absolute freedom in the acceptance and rejection of culture and civilization; it is pluralistic in their actions and in their consciousness. It is the subject of history and it should be creative, fluent mastering all the achievements of culture. Methodology. The dialogue system of the Postmodern, which is the basis of human communication with another person, human with society is a model of convergent formation of the world community and world economy. The same model of rationalism and adequate industrial society is a monologue, which is easily builds a bridge to violence, even if it is carried out in the name of the man behind him and the pathos of the exaltation of man as the bearer of unlimited creation possibilities. However, it is very important not just to modify rationalism, and to understand the origins of civilization. Scientific novelty. The postmodern era begins is not easy. Modern defending, using all their reserves: public thirst for justice, the priority of rationality, monologist public agencies and politicians in contrast to the dialogic postmodern imperative modality in the spiritual existence of man instead the freedom. Finally, the world of the story is set a trap – the anthropological paradigm of the globalization ideology formation. In this paradigm, people see materialistic rational measure of space and society building, i.e. the natural and social being, not a spiritual person. All this was evident in the course of transformation in Ukraine. Its main weakness is obvious. This narrows the field of mass participation in the market or by the adopted symbolism, the field of subjectivity. The population is invited to wait and endure, i.e. plays the role of the object of political and economic manipulation. Even more unacceptable monopolization of subjectivity government, for which everything is regarded as a subject of state regulation. Conclusions. For civilization of cardinal feature is the treatment of the person as the subject of history. The need for the development of civilization to increase the degree of subjectivity in an economy where people can express themselves freely and responsibly through a system of private property relations: economic entity is the subject of property. Policy enhancing the role of human rights and the development of the principle of subjectivity means deepening the democratic foundations of the state structure. In the social sphere the subjectivity is expressed in the individualization of the social existence of man and the personification of public relations and it is implemented through the mechanisms of liberal institutions. It seems that the civilizational unity of the economy, democratic state and liberal society has the value of a scientific paradigm. Whatever the great cultural peaks of the postmodern, the main processes of a new society formed at its foot: in the area of formation of public consciousness and public preferences with the mass participation of the individual in the economy, in the field of state-building and the formation of social institutions on the principles of Amateur participation. (shrink)

У статті зроблена спроба привернути увагу фахівців до такого напряму економіки й розваг, як гральний бізнес. Описано розвиток i стан цього бізнесу в США, Росiйськiй Федерацiї й Українi. Наголошено на перспективності розвитку грального бізнесу в Україні.

In this chapter we offer a reflection on the notion of sample representativeness from an interpretivist-qualitative perspective. Specifically we are looking into the idea of learning about a phenomenon through examining extraordinary individuals characterized by that phenomenon; to describe them we use the term ‘extraordinary’ as a noun, thereby building on Howard Gardner’s notion of ‘extraordinary minds’ (Gardner, 1997). We are looking at the ‘extraordinary’ in their professional socio-historical contexts, as the phenomena we are interested in cannot be divorced from (...) the contexts in which they are embedded. In this particular book chapter we are interested in the phenomenon of creativity, and the two research projects on which we base our argument are also concerned with creativity. However, we do not see any reason why similar considerations could not be made in other areas – but we do not suggest that a simple generalizability is possible. -/- The basis of our reflection are two research projects we have done in the past: In the first one, we conducted ‘insider interviews’ (the second-named author used to be a chef in Michelin-starred restaurants) with 18 extraordinary chefs in order to gain a better understanding of how creativity manifests itself socio-culturally in the culinary domain (Cousins, O’Gorman, & Stierand, 2010; Stierand, 2015; Stierand & Dörfler, 2012b, 2016; Stierand, Dörfler, & MacBryde, 2014; Stierand & Lynch, 2008). In the second one, we interviewed 20 extraordinary scientists, including 17 Nobel Laureates in order to gain a better understanding of cognitive complexity and how cognitive complexity is manifested in the socio-cultural acceptance of creative outcomes in the scientific world (Dörfler & Eden, 2014a, 2014b, 2017). -/- We have presented our research at various conferences, and, perhaps as we were so passionate about it, we have received a great deal of interest from others, mainly PhD students and early career researchers, who were keen to undertake similar research projects. But, although we believe that the methodological journey we have taken can be an excellent path to very interesting and meaningful research, we cannot wholeheartedly recommend it to junior colleagues, knowing the difficulties they will face when trying to justify their findings and methodological choices and the uncertain profits in the form of publication of the results (see an excellent overview of the difficulties and profits in Lebuda, 2014). We made our initial methodological choices, i.e. interviewing extraordinary chefs and scientists, purely intuitively that is, we just knew that the insights we could gain from these people would potentially lead to excellent findings. However, this is not an acceptable justification in the academic world. Therefore, we started to develop a framework for conducting this type of research, but we are not quite there yet. This reflection chapter is a midway point for taking stock of the convincing arguments we have developed over time and of the problems we still need to solve. (shrink)

I present a systematic interpretation of the foundational purpose of constructions in ancient Greek geometry. I argue that Greek geometers were committed to an operationalist foundational program, according to which all of mathematics—including its entire ontology and epistemology—is based entirely on concrete physical constructions. On this reading, key foundational aspects of Greek geometry are analogous to core tenets of 20th-century operationalist/positivist/constructivist/intuitionist philosophy of science and mathematics. Operationalism provides coherent answers to a range of traditional philosophical problems regarding classical mathematics, such (...) as the epistemic warrant and generality of diagrammatic reasoning, superposition, and the relation between constructivism and proof by contradiction. Alleged logical flaws in Euclid can be interpreted as sound operationalist reasoning. Operationalism also provides a compelling philosophical motivation for the otherwise inexplicable Greek obsession with cube duplication, angle trisection, and circle quadrature. Operationalism makes coherent sense of numerous specific choices made in this tradition, and suggests new interpretations of several solutions to these problems. In particular, I argue that: Archytas’s cube duplication was originally a single-motion machine; Diocles’s cissoid was originally traced by a linkage device; Greek conic section theory was thoroughly constructive, based on the conic compass; in a few cases, string-based constructions of conic sections were used instead; pointwise constructions of curves were rejected in foundational contexts by Greek mathematicians, with good reason. Operationalism enables us to view the classical geometrical tradition as a more unified and philosophically aware enterprise than has hitherto been recognised. (shrink)

The geometrical algebra hypothesis was once the received interpretation of Greek mathematics. In recent decades, however, it has become anathema to many. I give a critical review of all arguments against it and offer a consistent rebuttal case against the modern consensus. Consequently, I find that the geometrical algebra interpretation should be reinstated as a viable historical hypothesis.

Forma i materʹi︠a︡l v iskusstve -- Muzyka -- Zhivopisʹ -- Literatura -- Obnovlenie formy -- Kinematograf -- Si︠u︡zhet v kinematografe -- Chaplin -- Budushchnostʹ kino -- Zakli︠u︡chenie.

This essay concentrates on philosophizing that happens outside and in addition to planned philosophical discussions, philosophizing that comes alive in practice, that is intensified in children’s encounters with the world, with others, with language, in play. It contemplates how adults, educators and parents encounter children and are affected by children’s philosophical explorations. What is the role of the adult in children’s philosophical questioning? How can we respond to children’s philosophizing? What does it mean to do so? The essay explores philosophical (...) exercises for early childhood educators in a range of examples from literature – memoirs, autobiographies, fiction and works that play in between those. By thinking through these literary examples, it investigates how educators can prepare for philosophical encounters with children through exercises of reading and thinking. In doing so the essay experiments with a form of writing that itself becomes a philosophical exercise. Through the examples and exercises the essay suggests how early childhood educators can train for a pedagogical immediacy that involves listening to the philosophical and existential questioning in children’s play, tantrums, and silences. The investigations and readings of the examples are not meant to lead to conclusions that can be directly applied in pedagogical practices; neither do they work as arguments for listening or listening in a particular way to children. What we get, and what I am looking for, is rather the experience of working and thinking through these examples. (shrink)

A particularly strong reason to vaccinate against transmittable diseases, based on considerations of harm, is to contribute to the realization of population-level herd immunity. We argue, however, that herd immunity alone is insufficient for deriving a strong harm-based moral obligation to vaccinate in all circumstances, since the obligation significantly weakens well above and well below the herd immunity threshold. The paper offers two additional harm-based arguments that, together with the herd immunity argument, consolidates our moral obligation. First, we argue that (...) individuals should themselves aim not to expose others to risk of harm, and that this consideration becomes stronger the more non-vaccinated people there are, i.e., the further we are below herd immunity. Second, we elaborate on two pragmatic reasons to vaccinate beyond the realization of herd immunity, pertaining to instability of vaccination rates and population heterogeneity, and argue that vaccinating above the threshold should serve as a precautionary measure for buttressing herd immunity. We also show that considerations of harm have normative primacy in establishing this obligation over considerations of fairness. Although perfectly sound, considerations of fairness are, at worst secondary, or at best complementary to considerations of harm. (shrink)

This essay explores how moral discourse can have dogmatic tendencies. In exemplifying how it is possible to move beyond such tendencies, this essay turns to the Norwegian picture book Garmann's Summer. The essay not only suggests a vision of moral thinking, but also aims to demonstrate the role that literature, and particularly children's literature, can play in moral discourse, particularly in philosophy. The picture book's elaborations on the difficulties children can face when starting school show both what ethics beyond moral (...) concepts can be and the role that literature and art can have in moral thinking. The essay aims to show that moral work may consist in acknowledging difficulties and that all of their complexities have a role to play in the lives of real human beings. Accordingly, the essay is not a philosophical interpretation of a children's book, but an attempt to read a children's book to do philosophy. (shrink)

The paper points to gaps in the conceptualization of bullshit as offered by Harry Frankfurt and Jerry Cohen. I argue that one type of bullshit, obscurantism, the deliberate exercise of making one’s text opaque for the purposes of deceiving the readership in various ways, escapes Frankfurt’s radar in tracking those judgments that are unconcerned with truth, and is not given distinct status in Cohen’s framework, which pays more attention to the product of bullshit than its producers and their techniques. First, (...) I offer on overview of the expanding literature on bullshit, with special attention given to accounts by Frankfurt and Cohen. I claim that Frankfurt’s essentialism and Cohen’s product-oriented account are not successful in exhausting our common understanding of what bullshit entails, neither separately, nor in conjunction. In particular, I claim that obscurantist bullshit pushes the envelope of the current conceptual frameworks. Second, following Boudry’s and Buekens’s work on obscurantism, I discuss the usual mechanisms utilized by obscurantists. Third, I reflect on an objection to my argument based on tweaking the permissibility for producing obscurantism by placing the production of obscurities into different contexts of writing style. I argue that there is an important normative difference between being an obscurantist and someone who merely writes obscurely, and that the distinction should bear weight regardless of constraining our capacities to tell between the two. I finish by discussing whether our understanding of obscurantist bullshit aids us in following a principle of clarity. (shrink)

This investigation addresses the internal experience as a spatial phenomenon. Ascertaining the difference between internal and external experience as a space metaphor leads to the question of the source of the space metaphors in principle. The analogy between time and space and the space metaphors in Husserl’s conception of time are considered. The question of the temporality of consciousness, evidence, and internal experience are brought to the fore by comparing Brentano’s and Husserl’s conceptions. The difference between the direct and indirect (...) modes of consciousness by Brentano, his conception of time as the boundary in the continuum, and his concept of the proteraesthesis proves to be relevant for the concept of internal experience as a spatial phenomenon. The essay calls in question the self-sufficiency of time-experience and the traditional correspondence of time to the internal experience and of space to the external one. The relation of the Here/There- and Now/Then-experience is discussed. I intend to elucidate the experience of boundary as a primary internal experience from which the space-experience arises. In its turn the boundary-consciousness has its origin in the differentiation-experience. In the latter there is no time, the internal one included, but there is a boundary-experience as a primary and indirect experience. Time is s shadow of space; it originates from the manifold of human spaces.Esta investigación aborda la experiencia interna como un fenómeno espacial. Determinar la diferencia entre la experiencia interna y externa como una metáfora del espacio conduce a la cuestión de la fuente de las, en principio, metáforas espaciales. Aquí se atiende la analogía entre el tiempo y el espacio y las metáforas espaciales en la concepción del tiempo de Husserl. Se ponen de relieve la cuestión de la temporalidad de la conciencia, la evidencia y la experiencia interna, comparando las concepciones de Brentano y Husserl. La diferencia entre los modos de conciencia directos e indirectos de Brentano, su concepción del tiempo como el límite en el continuo, y su concepto de la proteroestesis, son relevantes para el concepto de experiencia interna como un fenómeno espacial. El ensayo cuestiona la autosuficiencia de la experiencia del tiempo y la correspondencia tradicional del tiempo con la experiencia interna y del espacio con la externa. Se discute la relación de la experiencia Aquí/Ahí y de la experiencia Ahora/Luego. Mi in-tención es esclarecer la experiencia de la frontera como una experiencia interna primaria de la cual surge la experiencia espacial. A su vez, la con-ciencia de frontera tiene su origen en la experiencia de diferenciación. En esta último no hay tiempo —incluso el interno—, pero hay una experiencia límite como experiencia primaria e indi-recta. El tiempo es la sombra del espacio; se origina en la multiplicidad de espacios humanos.. (shrink)

In this paper I investigate how philosophy can speak for children and how children can have a voice in philosophy and speak for philosophy. I argue that we should understand children as responsible rational individuals who are involved in their own philosophical inquiries and who can be involved in our own philosophical investigations—not because of their rational abilities, but because we acknowledge them as conversational partners, acknowledge their reasons as reasons, and speak for them as well as let them speak (...) for us and our rational community. In order to argue this I turn, first, to Gareth Matthews' philosophy of childhood and suggest a reconstruction of some of his concepts in line with the philosophy of Stanley Cavell. Second, in order to examine more closely our conceptions of rationality and our pictures of children, I consider the children's books, The Lorax and Where is My Sister? and Henrik Ibsen's play, The Wild Duck. (shrink)

Analyses in Greek geometry are traditionally seen as heuristic devices. However, many occurrences of analysis in formal treatises are difficult to justify in such terms. I show that Greek analysies of geometrics can also serve formal mathematical purposes, which are arguably incomplete without which their associated syntheses are arguably incomplete. Firstly, when the solution of a problem is preceded by an analysis, the analysis latter proves rigorously that there are no other solutions to the problem than those offered in the (...) synthesis. Secondly, whenever some construction assumption beyond ruler and compass is made, the problem is not only solvable by that assumption but is in fact equivalent to that assumption in a rigorous sense. (shrink)